Various methods have existed for removing the werewolf form. In antiquity, the Ancient Greeks and Romans believed in the power of exhaustion in curing people of lycanthropy. The victim would be subjected to long periods of physical activity in the hope of being purged of the malady. This practice stemmed from the fact that many alleged werewolves would be left feeling weak and debilitated after committing depredations.

In medieval Europe, traditionally, there are three methods one can use to cure a victim of lycanthropy; medicinally (usually via the use of wolfsbane), surgically, or by exorcism. However, many of the cures advocated by medieval medical practitioners proved fatal to the patients. A Sicilian belief of Arabic origin holds that a werewolf can be cured of its ailment by striking it on the forehead or scalp with a knife. Another belief from the same culture involves the piercing of the werewolf's hands with nails. Sometimes, less extreme methods were used. In the German lowland of Schleswig-Holstein, a werewolf could be cured if one were to simply address it three times by its Christian name, while one Danish belief holds that merely scolding a werewolf will cure it. Conversion to Christianity is also a common method of removing lycanthropy in the medieval period; a devotion to St. Hubert has also been cited as both cure for and protection from lycanthropes.